EIF6 Antibody
Produktgrößen
50ug
£305,00
OACA02900-50UG
100ug
£463,00
OACA02900-100UG
Über dieses Produkt
- SKU:
- OACA02900
- Zusätzliche Namen:
- b(2)gcn;B(2)GCN homolog;B4 integrin interactor;CAB;EIF3A;eIF-6;eukaryotic translation initiation factor 3A;eukaryotic translation initiation factor 6;ITGB4BP;p27 beta-4 integrin-binding protein;p27(BBP);p27BBP.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284; PubMed:14654845; PubMed:21536732). In tissues responsive to insulin; controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB; CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation; controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells; its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).
- Gendetails:
- eukaryotic translation initiation factor 6
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Eukaryotic translation initiation factor 6 protein (1-245AA)
- Isotyp:
- IgG
- Proteindetails:
- Eukaryotic translation initiation factor 6
- Reinheit:
- >95%
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php