AURKB Antibody
Produktgrößen
50ug
£305,00
OACA02634-50UG
100ug
£463,00
OACA02634-100UG
Über dieses Produkt
- SKU:
- OACA02634
- Zusätzliche Namen:
- AIK2;AIM1;AIM-1;ARK2;ARK-2;AurB;aurkb-sv1;aurkb-sv2;Aurora 1;aurora- and Ipl1-like midbody-associated protein 1;aurora kinase B;aurora kinase B-Sv1;aurora kinase B-Sv2;aurora/IPL1-related kinase 2;aurora-1;aurora-B;aurora-related kinase 2;IPL1;PPP1R48;protein phosphatase 1; regulatory subunit 48;serine/threonine kinase 12;serine/threonine-protein kinase 12;serine/threonine-protein kinase 5;serine/threonine-protein kinase aurora-B;STK-1;STK12;STK5.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC); a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint; a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C; leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861; PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin; CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA; DES/desmin; GPAF; KIF2C; NSUN2; RACGAP1; SEPT1; VIM/vimentin; HASPIN; and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process; whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph; respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells; inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
- Gendetails:
- aurora kinase B
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Aurora kinase B protein (1-255AA)
- Isotyp:
- IgG
- Proteindetails:
- Aurora kinase B
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php