ADAM10 Antibody
Produktgrößen
50ug
£305,00
OACA02538-50UG
100ug
£463,00
OACA02538-100UG
Über dieses Produkt
- SKU:
- OACA02538
- Zusätzliche Namen:
- a disintegrin and metalloprotease domain 10;AD10;AD18;CD156c;CDw156;disintegrin and metalloproteinase domain-containing protein 10;HsT18717;kuz;kuzbanian protein homolog;MADM;mammalian disintegrin-metalloprotease;RAK.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins; including heparin-binding epidermal growth-like factor; ephrin-A2; CD44; CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862; PubMed:11786905; PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles; suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711; PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146).
- Gendetails:
- ADAM metallopeptidase domain 10
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Disintegrin and metalloproteinase domain-containing protein 10 protein (214-504AA)
- Isotyp:
- IgG
- Proteindetails:
- Disintegrin and metalloproteinase domain-containing protein 10
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php