AGER Antibody - Biotin Conjugated
Produktgrößen
100ug
£478,00
OACA01950-100UG
Über dieses Produkt
- SKU:
- OACA01950
- Zusätzliche Namen:
- advanced glycosylation end product-specific receptor;RAGE;receptor for advanced glycation end-products variant 20;Receptor for advanced glycosylation end products;SCARJ1;sRAGE.
- Klonalität:
- Polyclonal
- Konjugat:
- Biotin
- Weitere Details:
- Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha; oxidative stress; and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium; mononuclear phagocytes; and lymphocytes triggers cellular activation; with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling; especially stimulation of p38 mitogen-activated protein kinase (MAPK); has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
- Gendetails:
- advanced glycosylation end-product specific receptor
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA)
- Isotyp:
- IgG
- Proteindetails:
- Advanced glycosylation end product-specific receptor
- Reinheit:
- Caprylic Acid Ammonium Sulfate Precipitation purified
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php