CHMP2A Antibody - HRP Conjugated
Produktgrößen
100ug
£478,00
OACA01168-100UG
Über dieses Produkt
- SKU:
- OACA01168
- Zusätzliche Namen:
- BC2;BC-2;charged multivesicular body protein 2a;CHMP2;chromatin modifying protein 2A;Chromatin-modifying protein 2a;putative breast adenocarcinoma marker (32kD);putative breast adenocarcinoma marker BC-2;vacuolar protein sorting-associated protein 2-1;VPS2;VPS2 homolog A;vps2-1;VPS2A.
- Klonalität:
- Polyclonal
- Konjugat:
- HRP
- Weitere Details:
- Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins; such as stimulated growth factor receptors; lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O; -I;-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events; such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST; the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities; possibly in conjunction with the AAA ATPase VPS4.
- Gendetails:
- charged multivesicular body protein 2A
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Charged multivesicular body protein 2a protein (1-222AA)
- Isotyp:
- IgG
- Proteindetails:
- Charged multivesicular body protein 2a
- Reinheit:
- Caprylic Acid Ammonium Sulfate Precipitation purified
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php