CTNNB1 Antibody - HRP Conjugated
Produktgrößen
100ug
£478,00
OACA00118-100UG
Über dieses Produkt
- SKU:
- OACA00118
- Zusätzliche Namen:
- armadillo;Beta-catenin;catenin (cadherin-associated protein); beta 1; 88kDa;catenin beta-1;CTNNB;EVR7;MRD19;NEDSDV.
- Klonalität:
- Polyclonal
- Konjugat:
- HRP
- Weitere Details:
- Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt; forms a complex with AXIN1; AXIN2; APC; CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand; CTNNB1 is not ubiquitinated and accumulates in the nucleus; where it acts as a coactivator for transcription factors of the TCF/LEF family; leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion; as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503; PubMed:18077326; PubMed:18086858; PubMed:18957423; PubMed:21262353; PubMed:22647378; PubMed:22699938; PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
- Gendetails:
- catenin beta 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Catenin beta-1 protein (2-781AA)
- Isotyp:
- IgG
- Proteindetails:
- Catenin beta-1
- Reinheit:
- Caprylic Acid Ammonium Sulfate Precipitation
- Aufreinigung:
- Protein G Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C or -80Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php