C9ORF72 Antibody
Produktgrößen
100ul
£597,00
OABF01871-100UL
Über dieses Produkt
- SKU:
- OABF01871
- Zusätzliche Namen:
- ALSFTD;DENND9;DENNL72;FTDALS;FTDALS1;guanine nucleotide exchange C9orf72;protein C9orf72.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 ug/ul
- Weitere Details:
- Component of the C9orf72-SMCR8 complex; a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190; PubMed:27103069; PubMed:27617292; PubMed:28195531). In the complex; C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP; converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form; thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6; leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin; leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity).
- Gendetails:
- C9orf72-SMCR8 complex subunit
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from human C9orf72
- Isotyp:
- IgG
- Proteindetails:
- Guanine nucleotide exchange C9orf72
- Aufreinigung:
- Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php