EIF2AK3 Antibody
Produktgrößen
100ul
£597,00
OABF01218-100UL
Über dieses Produkt
- SKU:
- OABF01218
- Zusätzliche Namen:
- eukaryotic translation initiation factor 2-alpha kinase 3;pancreatic eIF2-alpha kinase;PE;Pek;Perk;PRKR-like endoplasmic reticulum kinase.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 ug/ul
- Weitere Details:
- Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability (PubMed:11106749). Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor; leading to a reduced overall utilization of amino acids; or to a translation initiation activator of specific mRNAs; such as the transcriptional activator ATF4; and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:23921556). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (PubMed:11035797). Involved in control of mitochondrial morphology and function (PubMed:23921556).
- Gendetails:
- eukaryotic translation initiation factor 2 alpha kinase 3
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic phosphopeptide derived from mouse PERK around the phosphorylation site of Thr980
- Isotyp:
- IgG
- Proteindetails:
- Eukaryotic translation initiation factor 2-alpha kinase 3
- Aufreinigung:
- Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php