CYLD Antibody
Produktgrößen
100ul
£597,00
OABF01160-100UL
Über dieses Produkt
- SKU:
- OABF01160
- Zusätzliche Namen:
- BRSS;CDMT;CYLD1;CYLDI;cylindromatosis (turban tumor syndrome);deubiquitinating enzyme CYLD;EAC;FTDALS8;MFT;MFT1;probable ubiquitin carboxyl-terminal hydrolase CYLD;SBS;TEM;ubiquitin carboxyl-terminal hydrolase CYLD;ubiquitin specific peptidase like 2;ubiquitin thioesterase CYLD;ubiquitin thiolesterase CYLD;ubiquitin-specific-processing protease CYLD;USPL2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 ug/ul
- Weitere Details:
- Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689; PubMed:12917691). Contributes to the regulation of cell survival; proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics; and thereby contributes to the regulation of cell proliferation; cell polarization; cell migration; and angiogenesis (PubMed:18222923; PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026; PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response; via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells; but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis; allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and; together with OTULIN; restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26670046; PubMed:26997266).
- Gendetails:
- CYLD lysine 63 deubiquitinase
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic phosphopeptide derived from human CYLD around the phosphorylation site of Ser418
- Isotyp:
- IgG
- Proteindetails:
- Ubiquitin carboxyl-terminal hydrolase CYLD
- Aufreinigung:
- Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php