FZD5 Antibody
Produktgrößen
100ul
£597,00
OABF01116-100UL
Über dieses Produkt
- SKU:
- OABF01116
- Zusätzliche Namen:
- C2orf31;frizzled 5; seven transmembrane spanning receptor;frizzled 8; seven transmembrane spanning receptor;frizzled family receptor 5;frizzled family receptor 8;frizzled homolog 8;frizzled-5;frizzled-8;fz-5;FZ-8;fzE5;HFZ5;hFZ8;seven-transmembrane receptor frizzled-5;Wnt receptor.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 ug/ul
- Weitere Details:
- Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 5 protein is believed to be the receptor for the Wnt5A ligand. Frizzled 5 has been reported to be expressed in fetal kidney; fetal and adult liver; fetal lung; and adult pancreas. ESTs have been isolated from bone; liver/spleen; placenta; and prostate libraries. Frizzled 5 was cloned from a retina cDNA library. Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins; such as WNT1.
- Gendetails:
- frizzled class receptor 5|frizzled class receptor 8
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from human Frizzled 5
- Isotyp:
- IgG
- Aufreinigung:
- Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php