ATM Antibody
Produktgrößen
100ul
£597,00
OABF00664-100UL
Über dieses Produkt
- SKU:
- OABF00664
- Zusätzliche Namen:
- AI256621;A-T mutated homolog;ataxia telangiectasia gene mutated in human beings;ataxia telangiectasia mutated homolog;C030026E19Rik;serine-protein kinase ATM.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 ug/ul
- Weitere Details:
- Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs); apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA); thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs); thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion; a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele; acts by mediating a repositioning of the second allele to pericentromeric heterochromatin; preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2; CHEK2; p53/TP53; FANCD2; NFKBIA; BRCA1; CTIP; nibrin (NBN); TERF1; RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development; gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
- Gendetails:
- ataxia telangiectasia mutated
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from mouse ATM
- Isotyp:
- IgG
- Proteindetails:
- Serine-protein kinase ATM
- Aufreinigung:
- Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php