BRCA2 Antibody
Produktgrößen
100ul
£597,00
OABF00562-100UL
Über dieses Produkt
- SKU:
- OABF00562
- Zusätzliche Namen:
- BRCA1/BRCA2-containing complex; subunit 2;BRCC2;breast and ovarian cancer susceptibility gene; early onset;breast and ovarian cancer susceptibility protein 2;breast cancer 2 tumor suppressor;breast cancer 2; early onset;breast cancer type 2 susceptibility protein;BROVCA2;FACD;FAD;FAD1;FANCD;FANCD1;Fanconi anemia group D1 protein;GLM3;mutant BRCA2;PNCA2;truncated BRCA2 DNA repair associated;truncated BRCA2 DNA repair-associated protein;truncated breast cancer 2;truncated DNA repair-associated BRCA2;truncated DNA repair-associated protein;XRCC11.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 ug/ul
- Weitere Details:
- Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA; enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA; and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1; regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1; and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells; suggesting that BRCA2 mediates the control of R-loop associated genomic instability; independently of its known role in homologous recombination (PubMed:24896180).
- Gendetails:
- BRCA2 DNA repair associated
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from human BRCA2
- Isotyp:
- IgG
- Proteindetails:
- Breast cancer type 2 susceptibility protein
- Aufreinigung:
- Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php