CD36 Antibody
Produktgrößen
100ul
£597,00
OABF00459-100UL
Über dieses Produkt
- SKU:
- OABF00459
- Zusätzliche Namen:
- CD36 antigen;FA;FAT;fatty acid translocase;glycoprotein IIIb;GPIIIB;GPIV;PAS IV;PAS-4;platelet glycoprotein 4;platelet glycoprotein IV;Sca;Scarb3.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 ug/ul
- Weitere Details:
- Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin; fibronectin; collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL); anionic phospholipids; long-chain fatty acids and bacterial diacylated lipopeptides (PubMed:7685021). They are generally multivalent and can therefore engage multiple receptors simultaneously; the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis; inflammatory response; fatty acid metabolism; taste and dietary fat processing in the intestine (Probable) (PubMed:19847289; PubMed:20037584; PubMed:23395392). Binds long-chain fatty acids and facilitates their transport into cells; thus participating in muscle lipid utilization; adipose energy storage; and gut fat absorption (By similarity). In the small intestine; plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation; possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:17507371; PubMed:18753675; PubMed:21610069). Involved in oral fat perception and preferences (PubMed:16276419). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity) (PubMed:16276419). In taste receptor cells; mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids; leading to the activation of the gustatory neurons in the nucleus of the solitary tract (PubMed:18162488). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity) (PubMed:23557700). Receptor for thombospondins; THBS1 and THBS2; mediating their antiangiogenic effects (PubMed:15748999). As a coreceptor for TLR4:TLR6 heterodimer; promotes inflammation in monocytes/macrophages. Upon ligand binding; such as oxLDL or amyloid-beta 42; interacts with the heterodimer TLR4:TLR6; the complex is internalized and triggers inflammatory response; leading to NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion; through the priming and activation of the NLRP3 inflammasome (PubMed:20037584; PubMed:23812099). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer; this cluster triggers signaling from the cell surface; leading to the NF-kappa-B-dependent production of TNF; via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:15690042; PubMed:19847289).
- Gendetails:
- CD36 molecule
- Host:
- Rabbit
- Immunogen:
- KLH conjugated synthetic peptide derived from mouse CD36
- Isotyp:
- IgG
- Proteindetails:
- Platelet glycoprotein 4
- Aufreinigung:
- Protein A Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php