EHMT1 Antibody
Produktgrößen
50ul
£264,00
OAAN03863-50UL
100ul
£379,00
OAAN03863-100UL
200ul
£581,00
OAAN03863-200UL
Über dieses Produkt
- SKU:
- OAAN03863
- Zusätzliche Namen:
- GLP; GLP1; KMT1D; KLEFS1; FP13812; EHMT1-IT1; EUHMTASE1; Eu-HMTase1
- Klonalität:
- Polyclonal
- Weitere Details:
- Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2; respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation; the histone methyltransferase activity is not required for DNA methylation; suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6; MGA; MAX and/or DP1. During G0 phase; it probably contributes to silencing of MYC- and E2F-responsive genes; suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity; also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.
- Gendetails:
- euchromatic histone lysine methyltransferase 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Protein
- Isotyp:
- IgG
- Molekulargewicht:
- 141 kDa
- Proteindetails:
- Zinc finger protein 408
- Aufreinigung:
- Affinity purification
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquote and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php