FIP1L1 Antibody
Produktgrößen
50ul
£264,00
OAAN02155-50UL
100ul
£379,00
OAAN02155-100UL
200ul
£581,00
OAAN02155-200UL
Über dieses Produkt
- SKU:
- OAAN02155
- Zusätzliche Namen:
- Rhe; FIP1; hFip1
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene; the homolog of yeast Fip1 (factor interacting with PAP); binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor; alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome; recently reclassified as chronic eosinophilic leukemia (CEL); is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- Gendetails:
- factor interacting with PAPOLA and CPSF1
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human FIP1L1
- Isotyp:
- IgG
- Molekulargewicht:
- 67 kDa
- Proteindetails:
- Pre-mRNA 3'-end-processing factor FIP1
- Aufreinigung:
- Affinity purified against immunogen
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php