DDB1 Antibody
Produktgrößen
50ul
£264,00
OAAN00979-50UL
100ul
£379,00
OAAN00979-100UL
200ul
£581,00
OAAN00979-200UL
Über dieses Produkt
- SKU:
- OAAN00979
- Zusätzliche Namen:
- XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However; it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition; Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q; but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
- Gendetails:
- damage specific DNA binding protein 1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human DDB1
- Isotyp:
- IgG
- Molekulargewicht:
- 127 kDa
- Proteindetails:
- DNA damage-binding protein 1
- Aufreinigung:
- Affinity purified against immunogen
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php