ERG Antibody
Produktgrößen
50ul
£264,00
OAAN00315-50UL
100ul
£379,00
OAAN00315-100UL
200ul
£581,00
OAAN00315-200UL
Über dieses Produkt
- SKU:
- OAAN00315
- Zusätzliche Namen:
- p55; erg-3
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Weitere Details:
- This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development; cell proliferation; differentiation; angiogenesis; inflammation; and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium; inducing vascular cell remodeling. It also regulates hematopoesis; and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations; resulting in different fusion gene products; such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer; EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported; but the full-length nature of many of these variants has not been determined.
- Gendetails:
- v-ets avian erythroblastosis virus E26 oncogene homolog
- Host:
- Rabbit
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ERG (NP_891548.1).
- Isotyp:
- IgG
- Molekulargewicht:
- 60 kDa
- Proteindetails:
- Transcriptional regulator ERG
- Aufreinigung:
- Affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20°C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php