CEP152 Antibody
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100 uL
£446,00
OAAJ11764-100UL
Über dieses Produkt
- SKU:
- OAAJ11764
- Zusätzliche Namen:
- MCPH4; MCPH9; SCKL5
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Necessary for centrosome duplication; the function seems also to involve CEP63; CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ; 2 molecules involved in centriole formation. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles . Overexpression of CEP152 can drive amplification of centrioles.
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide derived from human CEP152
- Molekulargewicht:
- 140 kDa
- Proteindetails:
- Centrosomal protein of 152 kDa
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php