CCL5 Antibody
Produktgrößen
100 uL
£446,00
OAAJ07893-100UL
Über dieses Produkt
- SKU:
- OAAJ07893
- Zusätzliche Namen:
- SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Chemoattractant for blood monocytes; memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1; CCR3; CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1; HIV-2; and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. May also be an agonist of the G protein-coupled receptor GPR75; stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75; may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3; Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human CCL5
- Molekulargewicht:
- 9 kDa
- Proteindetails:
- C-C motif chemokine 5
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php