EFNA1 Antibody
Produktgrößen
100 uL
£446,00
OAAJ07750-100UL
Über dieses Produkt
- SKU:
- OAAJ07750
- Zusätzliche Namen:
- B61; EFL1; GMAN; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Cell surface GPI-bound ligand for Eph receptors; a family of receptor tyrosine kinases which are crucial for migration; repulsion and adhesion during neuronal; vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells; leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2; VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human EFNA1
- Molekulargewicht:
- 24 kDa
- Proteindetails:
- Ephrin-A1
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php