DDB1 Antibody
Produktgrößen
100 uL
£446,00
OAAJ07574-100UL
Über dieses Produkt
- SKU:
- OAAJ07574
- Zusätzliche Namen:
- XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD); 6-4 photoproducts (6-4 PP); apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1; CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A; histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC; which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.20
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human DDB1
- Molekulargewicht:
- 127 kDa
- Proteindetails:
- DNA damage-binding protein 1
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php