ATF2 Antibody
Produktgrößen
100 uL
£446,00
OAAJ07352-100UL
Über dieses Produkt
- SKU:
- OAAJ07352
- Zusätzliche Namen:
- HB16; CREB2; TREB7; CREB-2; CRE-BP1
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Transcriptional activator which regulates the transcription of various genes; including those involved in anti-apoptosis; cell growth; and DNA damage response. Dependent on its binding partner; binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus; contributes to global transcription and the DNA damage response; in addition to specific transcriptional activities that are related to cell development; proliferation and death. In the cytoplasm; interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane; thereby impairing mitochondrial membrane potential; inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1; promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human ATF2
- Molekulargewicht:
- 56 kDa
- Proteindetails:
- Cyclic AMP-dependent transcription factor ATF-2
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php