EIF6 Antibody
Produktgrößen
100 uL
£446,00
OAAJ07109-100UL
Über dieses Produkt
- SKU:
- OAAJ07109
- Zusätzliche Namen:
- CAB; EIF3A; eIF-6; p27BBP; ITGB4BP; b(2)gcn; p27(BBP)
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin; controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB; CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation; controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis . Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells; its activation seems to be rate-limiting in tumorigenesis and tumor growth .UniRule annotation
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human EIF6
- Molekulargewicht:
- 27 kDa
- Proteindetails:
- Eukaryotic translation initiation factor 6
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php