DTNBP1 Antibody
Produktgrößen
100 uL
£446,00
OAAJ06991-100UL
Über dieses Produkt
- SKU:
- OAAJ06991
- Zusätzliche Namen:
- SDY; DBND; HPS7; My031; BLOC1S8
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Component of the BLOC-1 complex; a complex that is required for normal biogenesis of lysosome-related organelles (LRO); such as platelet dense granules and melanosomes. In concert with the AP-3 complex; the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex; in association with SNARE proteins; is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1; modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human DTNBP1
- Molekulargewicht:
- 39 kDa
- Proteindetails:
- Dysbindin
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php