ELAVL1 Antibody
Produktgrößen
100 uL
£446,00
OAAJ06970-100UL
Über dieses Produkt
- SKU:
- OAAJ06970
- Zusätzliche Namen:
- HUR; Hua; MelG; ELAV1
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A); stabilizing them; promoting ESCs differentiation . Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element; binds to a core element of 27 nucleotides that contain AUUUA; AUUUUA; and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A; binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence; may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA .
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human ELAVL1
- Molekulargewicht:
- 36 kDa
- Proteindetails:
- ELAV-like protein 1
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php