FHIT Antibody
Produktgrößen
100 uL
£446,00
OAAJ06803-100UL
Über dieses Produkt
- SKU:
- OAAJ06803
- Zusätzliche Namen:
- FRA3B; AP3Aase
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A); but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival; such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds; but does not require its catalytic activity; it may in part come from the mitochondrial form; which sensitizes the low-affinity Ca2+ transporters; enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human FHIT
- Molekulargewicht:
- 17 kDa
- Proteindetails:
- Bis(5'-adenosyl)-triphosphatase
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php