EGLN1 Antibody
Produktgrößen
100 uL
£446,00
OAAJ06759-100UL
Über dieses Produkt
- SKU:
- OAAJ06759
- Zusätzliche Namen:
- HPH2; PHD2; SM20; ECYT3; HALAH; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Cellular oxygen sensor that catalyzes; under normoxic conditions; the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal; NODD; and C-terminal; CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions; the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus; heterodimerization with HIF1B; and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and; through regulating the stability of HIF1; involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human EGLN1
- Molekulargewicht:
- 46 kDa
- Proteindetails:
- Egl nine homolog 1
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php