E2F8 Antibody
Produktgrößen
100 uL
£446,00
OAAJ06743-100UL
Über dieses Produkt
- SKU:
- OAAJ06743
- Zusätzliche Namen:
- E2F-8
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1; thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle; probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1; E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis; possibly by acting as a transcription activator: associates with HIF1A; recognizes and binds the VEGFA promoter; which is different from canonical E2 recognition site; and activates expression of the VEGFA gene.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human E2F8
- Molekulargewicht:
- 94 kDa
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php