ATP2A2 Antibody
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100 uL
£446,00
OAAJ06714-100UL
Über dieses Produkt
- SKU:
- OAAJ06714
- Zusätzliche Namen:
- DD; DAR; ATP2B; SERCA2
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS; thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation .
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human ATP2A2
- Molekulargewicht:
- 115 kDa
- Proteindetails:
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php