CDK4 Antibody
Produktgrößen
100 uL
£446,00
OAAJ06576-100UL
Über dieses Produkt
- SKU:
- OAAJ06576
- Zusätzliche Namen:
- CMM3; PSK-J3
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex; cyclin D/CDK4/CDKN1B; required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Host:
- Rabbit
- Immunogen:
- Center-peptideof human CDK4
- Molekulargewicht:
- 34 kDa
- Proteindetails:
- Cyclin-dependent kinase 4
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php