ATF4 Antibody
Produktgrößen
100 uL
£446,00
OAAJ06482-100UL
Über dieses Produkt
- SKU:
- OAAJ06482
- Zusätzliche Namen:
- CREB2; TXREB; CREB-2; TAXREB67
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'); a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production . It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP; activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response; activates the transcription of NLRP1; possibly in concert with other factors.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human ATF4
- Molekulargewicht:
- 39 kDa
- Proteindetails:
- Cyclic AMP-dependent transcription factor ATF-4
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php