DMTN Antibody
Produktgrößen
100 uL
£446,00
OAAJ06405-100UL
Über dieses Produkt
- SKU:
- OAAJ06405
- Zusätzliche Namen:
- DMT; EPB49
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1; and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets; functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions; such as filopodia and lamellipodia; necessary for platelet cell spreading; motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide derived from human Dematin (Phospho-Ser403)
- Molekulargewicht:
- 45 kDa
- Proteindetails:
- Dematin
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php