FZD6 Antibody
Produktgrößen
100 uL
£446,00
OAAJ05806-100UL
Über dieses Produkt
- SKU:
- OAAJ05806
- Zusätzliche Namen:
- FZ6; FZ-6; HFZ6; NDNC1; NDNC10
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway; which leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3; is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP); particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear .
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide
- Molekulargewicht:
- 79 kDa
- Proteindetails:
- Frizzled-6
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php