FEN1 Antibody
Produktgrößen
100 uL
£446,00
OAAJ04061-100UL
Über dieses Produkt
- SKU:
- OAAJ04061
- Zusätzliche Namen:
- MF1; RAD2; FEN-1
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/mL
- Weitere Details:
- Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication; cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base; leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway; by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA; and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.UniRule annotation
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide
- Molekulargewicht:
- 42 kDa
- Proteindetails:
- Flap endonuclease 1
- Aufreinigung:
- Immunogen affinity chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php