GABBR1 Antibody
Produktgrößen
100 ul
£446,00
OAAJ01761-100UL
Über dieses Produkt
- SKU:
- OAAJ01761
- Zusätzliche Namen:
- GB1; GPRC3A; GABABR1; GABBR1-3
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- GABBR1 Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity; stimulates phospholipase A2; activates potassium channels; inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels; whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation; slow wave sleep; muscle relaxation and antinociception. Activated by (-)-baclofen; cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.
- Gendetails:
- gamma-aminobutyric acid (GABA) B receptor; 1
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide derived from human GABBR1
- Molekulargewicht:
- 110 kDa
- Aufreinigung:
- Affinity-chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Stable for 12 months from date of receipt.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php