Anti- Beta -Catenin Antibody
Produktgrößen
100ug
£413,00
OAAI00543-100UG
Über dieses Produkt
- SKU:
- OAAI00543
- Zusätzliche Namen:
- BCDS2;cadherin-associated Src substrate;CAS;catenin (cadherin-associated protein); delta 1;catenin delta-1;CTNND;p120;p120 catenin;p120(CAS);p120(CTN);P120CAS;P120CTN.
- Klonalität:
- Polyclonal
- Konzentration:
- 100ug/200ul
- Weitere Details:
- Beta-catenin is a cytosolic; 88 kDa; 781 amino acid protein belongs to the beta-catenin family. The N-terminus domain; containing the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin(s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors; initiating gene expression. Normally; beta-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3beta and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates beta-catenin at multiple sites; including S33 and S37; Y96; Y228; Y280 etc. Phosphorylation of beta-catenin targets the molecule for degradation via a ubiquination-mediated pathway. GSK3beta activity can be blocked by upstream signaling events such as Wnt-Frizzled interaction. This inhibits GSK3beta; allowing unphosphorylated beta-catenin to enter the nucleus and initiate gene activation. The phosphorylation of beta-catenin might contribute to tumorigenesis.
- Gendetails:
- catenin delta 1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the epitope DNYGS without phosphorylation of human -catenin.
- Isotyp:
- Rabbit IgG
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php