Anti-GSK-3 Beta Antibody
Produktgrößen
100ug
£413,00
OAAI00365-100UG
Über dieses Produkt
- SKU:
- OAAI00365
- Zusätzliche Namen:
- glycogen synthase kinase-3 beta;GSK-3 beta;serine/threonine-protein kinase GSK3B.
- Klonalität:
- Polyclonal
- Konzentration:
- 100ug/200ul
- Weitere Details:
- Glycogen Synthase Kinase-3beta (GSK-3beta) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. Growth factor (such as Insulin) binds to its receptor; recruits PKB/AKT kinase to phosphorylate GSK-3beta on Serine 9; which prevents GSK-3beta from phosphorylating glycogen synthase. In contrast; the phosphorylation of tyrosine 216 in the catalytic domain increase this kinase activity to promote cell death under the absence of growth factors. GSK-3beta is also involved in Wnt signaling pathway where it forms a complex with axin; beta-catenin and adenomatous polyposis coli (APC) protein; thus the GSK-3beta inhibitor is considered as a potential approach in Alzheimer's Disease (AD) treatment.
- Gendetails:
- glycogen synthase kinase 3 beta
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide surrounding to the epitope -TTSFA- without phosphorylation of human GSK3-beta protein. This sequence is identical among human; mouse; rat; bovine; dog and chicken species.
- Isotyp:
- Rabbit IgG
- Molekulargewicht:
- 48-52
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php