CD163 Antibody
Produktgrößen
0.05ml
£348,00
OAAF08253-0.05ML
0.1ml
£478,00
OAAF08253-0.1ML
Über dieses Produkt
- SKU:
- OAAF08253
- Zusätzliche Namen:
- hemoglobin scavenger receptor;M130;macrophage-associated antigen;MM130;SCARI1;scavenger receptor cysteine-rich type 1 protein M130.
- translate.label.attr.clone:
- ABT-CD163
- Klonalität:
- Monoclonal
- Weitere Details:
- Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron; via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization; inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
- Gendetails:
- CD163 molecule
- Host:
- Mouse
- Immunogen:
- Synthetic peptide
- Isotyp:
- IgG
- Molekulargewicht:
- 125 kDa
- Proteindetails:
- Scavenger receptor cysteine-rich type 1 protein M130
- Aufreinigung:
- Immunogen affinity purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php