CMTM6 Antibody
Produktgrößen
100 ug
£496,00
OAAF08167-100UG
Über dieses Produkt
- SKU:
- OAAF08167
- Zusätzliche Namen:
- chemokine-like factor super family 6;chemokine-like factor superfamily 6;chemokine-like factor superfamily member 6;CKLF-like MARVEL transmembrane domain-containing protein 6;CKLFSF6;PRO2219.
- Klonalität:
- Polyclonal
- Konzentration:
- 1mg/ml
- Weitere Details:
- Master regulator of recycling and plasma membrane expression of PD-L1/CD274; an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes; where it protects PD-L1/CD274 from being targeted for lysosomal degradation; likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279; its receptor on T-cells; ultimately triggering T-cell anergy.
- Gendetails:
- CKLF like MARVEL transmembrane domain containing 6
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from the C-terminal region of human CMTM6.
- Molekulargewicht:
- 20 kDa
- Proteindetails:
- CKLF-like MARVEL transmembrane domain-containing protein 6
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using peptide.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php