GDF5 Antibody
Produktgrößen
100 ug
£496,00
OAAF08159-100UG
Über dieses Produkt
- SKU:
- OAAF08159
- Zusätzliche Namen:
- BDA1C;BMP14;BMP-14;bone morphogenetic protein 14;Cartilage-derived morphogenetic protein 1;cartilage-derived morphogenetic protein-1;CDMP1;DUPANS;growth/differentiation factor 5;LAP4;LAP-4;lipopolysaccharide-associated protein 4;LPS-associated protein 4;OS5;radotermin;SYM1B;SYNS2.
- Klonalität:
- Polyclonal
- Konzentration:
- 1mg/ml
- Weitere Details:
- Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly; positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A; leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149; PubMed:21976273; PubMed:15530414; PubMed:25092592). Secondly; negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response; including TNF secretion by monocytes (PubMed:11276205).
- Gendetails:
- growth differentiation factor 5
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from the Internal region of human GDF5.
- Isotyp:
- IgG
- Molekulargewicht:
- 55 kDa
- Proteindetails:
- Growth/differentiation factor 5
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php