ATF2 Antibody
Produktgrößen
100 ug
£496,00
OAAF07680-100UG
Über dieses Produkt
- SKU:
- OAAF07680
- Zusätzliche Namen:
- Activating transcription factor 2;activating transcription factor 2 splice variant ATF2-var2;cAMP response element-binding protein CRE-BP1;cAMP responsive element binding protein 2; formerly;cAMP-dependent transcription factor ATF-2;CREB2;CREB-2;CRE-BP1;cyclic AMP-dependent transcription factor ATF-2;cyclic AMP-responsive element-binding protein 2;HB16;histone acetyltransferase ATF2;TREB7.
- Klonalität:
- Polyclonal
- Konzentration:
- 1mg/ml
- Weitere Details:
- Transcriptional activator which regulates the transcription of various genes; including those involved in anti-apoptosis; cell growth; and DNA damage response. Dependent on its binding partner; binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus; contributes to global transcription and the DNA damage response; in addition to specific transcriptional activities that are related to cell development; proliferation and death. In the cytoplasm; interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane; thereby impairing mitochondrial membrane potential; inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1; promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
- Gendetails:
- activating transcription factor 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human ATF2 around the phosphorylation site of Thr73 or 55.
- Molekulargewicht:
- 52 kDa
- Proteindetails:
- Cyclic AMP-dependent transcription factor ATF-2
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php