Dematin Antibody
Produktgrößen
100 ug
£496,00
OAAF07545-100UG
Über dieses Produkt
- SKU:
- OAAF07545
- Zusätzliche Namen:
- dematin;Dematin actin-binding protein;DMT;EPB49;Erythrocyte membrane protein band 4.9;erythrocyte membrane protein band 4.9 (dematin).
- Klonalität:
- Polyclonal
- Konzentration:
- 1mg/ml
- Weitere Details:
- Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1; and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets; functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions; such as filopodia and lamellipodia; necessary for platelet cell spreading; motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
- Gendetails:
- dematin actin binding protein
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Dematin around the phosphorylation site of Ser403.
- Molekulargewicht:
- 45 kDa
- Proteindetails:
- Dematin
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php