FZD6 Antibody
Produktgrößen
100 ug
£496,00
OAAF04891-100UG
Über dieses Produkt
- SKU:
- OAAF04891
- Zusätzliche Namen:
- frizzled 6; seven transmembrane spanning receptor;frizzled family receptor 6;frizzled homolog 6;frizzled-6;FZ6;FZ-6;HFZ6;NDNC1;NDNC10;seven transmembrane helix receptor.
- Klonalität:
- Polyclonal
- Weitere Details:
- Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway; which leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3; is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP); particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
- Gendetails:
- frizzled class receptor 6
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FZD6.
- Molekulargewicht:
- 79 kDa
- Proteindetails:
- Frizzled-6
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php