FZD4 Antibody
Produktgrößen
100 ug
£496,00
OAAF04889-100UG
Über dieses Produkt
- SKU:
- OAAF04889
- Zusätzliche Namen:
- CD344;EVR1;FEVR;frizzled 4; seven transmembrane spanning receptor;frizzled family receptor 4;frizzled homolog 4;frizzled-4;Fz4;Fz-4;FZD4S;FzE4;GPCR;hFz4;WNT receptor frizzled-4.
- Klonalität:
- Polyclonal
- Weitere Details:
- Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway; which leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina; it can be both activated by Wnt protein-binding; but also by a Wnt-independent signaling via binding of norrin (NDP); promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
- Gendetails:
- frizzled class receptor 4
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FZD4.
- Molekulargewicht:
- 59 kDa
- Proteindetails:
- Frizzled-4
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php