FFAR2 Antibody
Produktgrößen
100 ug
£496,00
OAAF04882-100UG
Über dieses Produkt
- SKU:
- OAAF04882
- Zusätzliche Namen:
- fatty acid receptor 2;FFA2R;free fatty acid activated receptor 2;free fatty acid receptor 2;GPR43;G-protein coupled receptor 43.
- Klonalität:
- Polyclonal
- Weitere Details:
- G protein-coupled receptor that is activated by a major product of dietary fiber digestion; the short chain fatty acids (SCFAs); and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals; the short chain fatty acids acetate; propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive; G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283; PubMed:12711604; PubMed:23589301). Its activation results in the formation of inositol 1;4;5-trisphosphate; the mobilization of intracellular calcium; the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1; in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin; a hormone acting on the central nervous system to inhibit food intake. Finally; may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis; may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine; regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs; may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs; the fatty acids containing less than 6 carbons; the most potent activators are probably acetate; propionate and butyrate (PubMed:12496283; PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).
- Gendetails:
- free fatty acid receptor 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FFAR2.
- Molekulargewicht:
- 37 kDa
- Proteindetails:
- Free fatty acid receptor 2
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php