CCBP2 Antibody
Produktgrößen
100 ug
£496,00
OAAF04863-100UG
Über dieses Produkt
- SKU:
- OAAF04863
- Zusätzliche Namen:
- atypical chemokine receptor 2;C-C chemokine receptor D6;CCBP2;CC-chemokine-binding receptor JAB61;CCR10;CCR9;chemokine (C-C motif) receptor 9;chemokine (C-C) receptor 9;chemokine receptor CCR-10;chemokine receptor CCR-9;chemokine receptor D6;chemokine-binding protein 2;chemokine-binding protein D6;CMKBR9;D6;hD6.
- Klonalität:
- Polyclonal
- Weitere Details:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine sequestration; degradation; or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2; CCL3; CCL3L1; CCL4; CCL5; CCL7; CCL8; CCL11; CCL13; CCL17; CCL22; CCL23; CCL24; SCYA2/MCP-1; SCY3/MIP-1-alpha; SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation; activates a beta-arrestin 1 (ARRB1)-dependent; G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane; increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues; on the surfaces of lymphatic vessels; and in placenta; plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
- Gendetails:
- atypical chemokine receptor 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CCBP2.
- Molekulargewicht:
- 43 kDa
- Proteindetails:
- Atypical chemokine receptor 2
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php