FZD8 Antibody
Produktgrößen
100 ug
£496,00
OAAF04821-100UG
Über dieses Produkt
- SKU:
- OAAF04821
- Zusätzliche Namen:
- C2orf31;frizzled 5; seven transmembrane spanning receptor;frizzled 8; seven transmembrane spanning receptor;frizzled family receptor 5;frizzled family receptor 8;frizzled homolog 8;frizzled-5;frizzled-8;fz-5;FZ-8;fzE5;HFZ5;hFZ8;seven-transmembrane receptor frizzled-5;Wnt receptor.
- Klonalität:
- Polyclonal
- Weitere Details:
- Receptor for Wnt proteins (PubMed:9054360; PubMed:10097073; PubMed:20530549). Can activate WNT2; WNT10B; WNT5A; but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons; activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).|Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins; such as WNT1.
- Gendetails:
- frizzled class receptor 5|frizzled class receptor 8
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FZD8.
- Molekulargewicht:
- 73 kDa
- Proteindetails:
- Frizzled-5|Frizzled-8
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php