FZD1 Antibody
Produktgrößen
100 ug
£496,00
OAAF04813-100UG
Über dieses Produkt
- SKU:
- OAAF04813
- Zusätzliche Namen:
- frizzled 1; seven transmembrane spanning receptor;frizzled family receptor 1;frizzled homolog 1;frizzled; Drosophila; homolog of; 1;frizzled-1;fz-1;fzE1;hFz1;Wnt receptor.
- Klonalität:
- Polyclonal
- Weitere Details:
- Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A; WNT3; WNT1 and to a lesser extent WNT2; but apparently not by WNT4; WNT5A; WNT5B; WNT6; WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
- Gendetails:
- frizzled class receptor 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FZD1.
- Molekulargewicht:
- 71 kDa
- Proteindetails:
- Frizzled-1
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php