APOBEC3D/F Antibody
Produktgrößen
100 ug
£496,00
OAAF04061-100UG
Über dieses Produkt
- SKU:
- OAAF04061
- Zusätzliche Namen:
- A3D;A3DE;A3F;APOBEC3DE;APOBEC3E;apolipoprotein B editing enzyme catalytic polypeptide-like 3F;apolipoprotein B mRNA editing enzyme cytidine deaminase;apolipoprotein B mRNA editing enzyme; catalytic polypeptide-like 3D;apolipoprotein B mRNA editing enzyme; catalytic polypeptide-like 3E pseudogene;apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F;ARP6;ARP8;BK150C2.4.MRNA;DNA dC->dU-editing enzyme APOBEC-3D;DNA dC->dU-editing enzyme APOBEC-3F;induced upon T-cell activation;KA6;probable DNA dC->dU-editing enzyme APOBEC-3D.
- Klonalität:
- Polyclonal
- Weitere Details:
- DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription; it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA; leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome; along with a deamination-independent mechanism that works prior to the proviral integration; together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV); equine infectious anemia virus (EIAV); xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.|DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription; it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA; leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome; along with a deamination-independent mechanism that works prior to the proviral integration; together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.
- Gendetails:
- apolipoprotein B mRNA editing enzyme catalytic subunit 3D|apolipoprotein B mRNA editing enzyme catalytic subunit 3F
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human APOBEC3D/F.
- Molekulargewicht:
- 46 kDa
- Proteindetails:
- DNA dC->dU-editing enzyme APOBEC-3D|DNA dC->dU-editing enzyme APOBEC-3F
- Aufreinigung:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php