EIF3D Antibody
Produktgrößen
100 ug
£496,00
OAAF03659-100UG
Über dieses Produkt
- SKU:
- OAAF03659
- Zusätzliche Namen:
- eIF3 p66;eIF3-p66;EIF3S7;eIF3-zeta;eIF-3-zeta;Eukaryotic translation initiation factor 3 subunit 7;eukaryotic translation initiation factor 3 subunit D;eukaryotic translation initiation factor 3; subunit 7 zeta; 66/67kDa;translation initiation factor eIF3 p66 subunit.
- Klonalität:
- Polyclonal
- Weitere Details:
- mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex; a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1; eIF-1A; eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441; PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation; including cell cycling; differentiation and apoptosis; and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex; EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).
- Gendetails:
- eukaryotic translation initiation factor 3 subunit D
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human EIF3D.
- Molekulargewicht:
- 63 kDa
- Proteindetails:
- Eukaryotic translation initiation factor 3 subunit D
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php